By Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr. Kurt Widhalm, Dr. Jochen Jarausch (eds.)
There is expanding facts for the clinicial price of the apo lipoprotein measurements. along with ldl cholesterol in plasma and li poprotein fractions, that is presently used as a trademark of cardiovascular possibility, the dimension of the AI and B apolipopro teins supplies more information in regards to the sufferers' medical prestige. a number of reviews exhibit that apo B is larger and apo AI is reduce in sufferers with angiographically documented heart dis ease than in symptomatic sufferers with out heart ailment. furthermore, discriminant research indicated that the focus of Apo AI and B in plasma are higher discriminators than lipo protein ldl cholesterol for selecting sufferers with heart illness. In a few stories the apo Bjapo AI ratio seems to be a extra strong predictor than person lipoproteins. In a contemporary examine performed in males, apolipoproteins AI and B have been higher correlated with the severity of heart problems than HDL and cholesterol. The predictive strength of apolipoproteins may possibly even if now not be confirmed in all reviews and the worth of apolipoprotein measurements within the box of scientific chemistry continues to be debatable. this can be most likely as a result of discrepancies among the result of a variety of reviews, bobbing up from variations within the kind of immunoassays, the inability of common reference fabrics, vary ences among learn protocols, diversifications within the collection of sufferers and within the grading and interpretation of coronary lesions.
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Extra info for Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring
0003 U5 - >. 30 (0 u.. j ~ c: 40 ~ 20 C Q) E Q) 10 ~ 0 > c: 0 0 40 60 80 100 120 140 LDL-C [mg/dl] Fig. I. Atherosclerotic fatty-streak involvement of the aorta related to levels of low-density lipoprotein cholesterol (LDL-C) in 30 young persons the children of persons with premature myocardial infarction (MI) and hyperapobetalipoproteinemia. Offspring from "risk" and "non-risk" families There are few studies with children offamilies with premature MI investigating whether it is possible to discriminate between a risk group from a non-risk group measuring lipoproteins and apolipoproteins [3, 4].
Are there specific considerations for normal probands and for patients with metabolic disease, such as diabetes (type I and type II), hypercholesterolemia, hypertriglyceridemia and hypertension? Materials and methods All assays were performed in duplicate on a COBAS® Mira Autoanalyzer (Roche, Basie, Switzerland). For purposes of comparison, we measured apo AI and apo B by nephelometry also on a Beckman Array System (Beckman Instruments, Berkeley, CA, USA). Cholesterol and triglycerides (TG) were determined as described previously [I].
Maciejko JJ, Holmes DR, Kottke BA, Zinsmeister AR, Dinh DM, Mao SJ (1983) Apolipoprotein AI as a marker of angiographically assessed coronary artery disease. N Engl J Med 309: 385-389 25. Miller NE (1987) Associations of high lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis. Am Heart J 113: 589-597 26. Murai A, Miyahara T, Fujimoto N (1986) Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction. Atherosclerosis 59: 199-204 27.
Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring by Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr. Kurt Widhalm, Dr. Jochen Jarausch (eds.)