By Alton Meister
Site visitors ATPases: A Superfamily of shipping Proteins working from Escherichia coli to people (G. Ames, et al.).
The respiration Burst Oxidase (B. Babior).
seasoned- and Antioxidant features of Quinones and Quinone Reductase in Mammalian Cells (E. Cadenas & P. Hochstein).
The Redox facilities of Ribonucleotide Reductase of Escherichia coli (M. Fontecave, et al.).
lengthy diversity Intramolecular associated capabilities within the Calcium shipping ATPase (G. Inesi, et al.).
Hydrogen-Bonding in Carbohydrates and Hydrate Inclusion Compounds (G. Jeffrey).
Methylation of mRNA (P. Narayan & F. Rottman).
Mammalian Nitric Oxide Synthases (D. Stuehr & O. Griffith).
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Extra resources for Advances in Enzymology and Related Areas of Molecular Biology, Volume 65
And Petsko, G. A. (1990). Cystic fibrosis. A transport problem? Nature, 346, 312-313. TRAFFIC ATPaser 47 Riordan, J. , Rommens, J . , Kozmahel, K . , GrLelczak. Z . , Zielenski, J . , Plavsic, N . -L.. Drumm, M. , Iannuzzi, M. , Collins, F. S . -C. (1989). Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA, S(,iPnce,245, 1066- 1073. , Sewell, J . , Biedler, J . , and Felsted, R. (1987). Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.
By using this system it 34 GIOVANNA AMES ET AL. ,plateau conditions), are the accumulated histidine and the ADP produced by ATP hydrolysis, both of which inhibit the uptake process. This finding leads to a hypothesis in which ATP hydrolysis results in a conformational change(s) that brings the substrate bound to the membrane complex from the outer to the inner surface of the membrane, thus allowing its release internally and the return of the empty site in the complex to the external surface (Fig.
Higgins, C. , Haag, P. , and Ames, G. -L. (1982). Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S . typhimurium, Nuture, 298, 723727. Higgins, C. , Hiles, 1. , Salmond, G. P. , Gill, D. , Downie, J. , Evans, I. , Holland, 1. ,Buckel, S . , Bell, A. , and Hermodson, M. TRAFFIC ATPases 45 A . (1986). A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria, Narure, 323. 448-450. Higgins, C. , Hiles, 1.
Advances in Enzymology and Related Areas of Molecular Biology, Volume 65 by Alton Meister